In the biomarkers is the protein molecule Fetuin-A, in the liver and blood to be delivered. High blood levels of the biomarker with a three-to fourfold increased risk of heart attack and stroke combined.
"Already some time ago we observed that increased Fetuin-A levels in the blood with a reduced insulin sensitivity of body cells, and may be given to increasing the storage of fat in the liver indicates," Haering said Ullrich, director of the Medical Clinic IV of the University Hospital in Tuebingen.
But now we know that Fetuin-A not only as a risk marker for type 2 diabetes in question. There is also a strong correlation between Fetuin-A-mirrors and cardiovascular diseases and regardless of risk factors such as hypertension, smoking and diabetes. Persons with a very high Fetuin-A blood value in comparison to those with a low value is a 3.3-fold increased risk of heart attack or a 3.8 fold increased risk of stroke.
During the average follow-up period of 8.2 years, 227 study participants suffered the more than 27,000 adults observed a heart attack. At 168 participants Doctors diagnosed ischemic stroke (An ischemic stroke is a sudden emptiness induced blood brain infarction). "The connection we observed between increased Fetuin-A-mirrors in the blood and an increased risk for cardiovascular disease is exceptionally strong," said Cornelia Weikert, epidemiologist at the German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE).
Therefore, we hope, Fetuin-A not only as biomarkers to be able to deploy. Man wanted Fetuin-A as a new starting point, to the heart attack and stroke underlying pathogenic mechanisms to investigate and better understand. "Our results suggest that the liver metabolism and especially the fatty liver for the emergence of cardiovascular disease plays an important role," said Andreas Fritsche of the Medical Clinic IV of the University Hospital in Tuebingen.
"Already some time ago we observed that increased Fetuin-A levels in the blood with a reduced insulin sensitivity of body cells, and may be given to increasing the storage of fat in the liver indicates," Haering said Ullrich, director of the Medical Clinic IV of the University Hospital in Tuebingen.
But now we know that Fetuin-A not only as a risk marker for type 2 diabetes in question. There is also a strong correlation between Fetuin-A-mirrors and cardiovascular diseases and regardless of risk factors such as hypertension, smoking and diabetes. Persons with a very high Fetuin-A blood value in comparison to those with a low value is a 3.3-fold increased risk of heart attack or a 3.8 fold increased risk of stroke.
During the average follow-up period of 8.2 years, 227 study participants suffered the more than 27,000 adults observed a heart attack. At 168 participants Doctors diagnosed ischemic stroke (An ischemic stroke is a sudden emptiness induced blood brain infarction). "The connection we observed between increased Fetuin-A-mirrors in the blood and an increased risk for cardiovascular disease is exceptionally strong," said Cornelia Weikert, epidemiologist at the German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE).
Therefore, we hope, Fetuin-A not only as biomarkers to be able to deploy. Man wanted Fetuin-A as a new starting point, to the heart attack and stroke underlying pathogenic mechanisms to investigate and better understand. "Our results suggest that the liver metabolism and especially the fatty liver for the emergence of cardiovascular disease plays an important role," said Andreas Fritsche of the Medical Clinic IV of the University Hospital in Tuebingen.
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